Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Autocrine vitamin D signaling switches off pro-inflammatory programs of T_H1 cells.

Chauss, Daniel; Freiwald, Tilo; McGregor, Reuben; Yan, Bingyu; Wang, Luopin; Nova-Lamperti, Estefania; Kumar, Dhaneshwar; Zhang, Zonghao; Teague, Heather; West, Erin E; Vannella, Kevin M; Ramos-Benitez, Marcos J; Bibby, Jack; Kelly, Audrey; Malik, Amna; Freeman, Alexandra F; Schwartz, Daniella M; Portilla, Didier; Chertow, Daniel S; John, Susan; Lavender, Paul; Kemper, Claudia; Lombardi, Giovanna; Mehta, Nehal N; Cooper, Nichola; Lionakis, Michail S; Laurence, Arian; Kazemian, Majid; Afzali, Behdad.

Nat Immunol ; 23(1): 62-74, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34764490

2.

Human retinoic acid-regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa.

Povoleri, Giovanni A M; Nova-Lamperti, Estefania; Scottà, Cristiano; Fanelli, Giorgia; Chen, Yun-Ching; Becker, Pablo D; Boardman, Dominic; Costantini, Benedetta; Romano, Marco; Pavlidis, Polychronis; McGregor, Reuben; Pantazi, Eirini; Chauss, Daniel; Sun, Hong-Wei; Shih, Han-Yu; Cousins, David J; Cooper, Nichola; Powell, Nick; Kemper, Claudia; Pirooznia, Mehdi; Laurence, Arian; Kordasti, Shahram; Kazemian, Majid; Lombardi, Giovanna; Afzali, Behdad.

Nat Immunol ; 19(12): 1403-1414, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30397350

3.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali, Behdad; Grönholm, Juha; Vandrovcova, Jana; O'Brien, Charlotte; Sun, Hong-Wei; Vanderleyden, Ine; Davis, Fred P; Khoder, Ahmad; Zhang, Yu; Hegazy, Ahmed N; Villarino, Alejandro V; Palmer, Ira W; Kaufman, Joshua; Watts, Norman R; Kazemian, Majid; Kamenyeva, Olena; Keith, Julia; Sayed, Anwar; Kasperaviciute, Dalia; Mueller, Michael; Hughes, Jason D; Fuss, Ivan J; Sadiyah, Mohammed F; Montgomery-Recht, Kim; McElwee, Joshua; Restifo, Nicholas P; Strober, Warren; Linterman, Michelle A; Wingfield, Paul T; Uhlig, Holm H; Roychoudhuri, Rahul; Aitman, Timothy J; Kelleher, Peter; Lenardo, Michael J; O'Shea, John J; Cooper, Nichola; Laurence, Arian D J.

Nat Immunol ; 18(7): 813-823, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28530713

4.

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

Schwartz, Daniella M; Farley, Taylor K; Richoz, Nathan; Yao, Chen; Shih, Han-Yu; Petermann, Franziska; Zhang, Yuan; Sun, Hong-Wei; Hayes, Erika; Mikami, Yohei; Jiang, Kan; Davis, Fred P; Kanno, Yuka; Milner, Joshua D; Siegel, Richard; Laurence, Arian; Meylan, Françoise; O'Shea, John J.

Immunity ; 50(1): 106-120.e10, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30650370

5.

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou, Chaido; Gangaplara, Arunakumar; Mallett, Grace; Flomerfelt, Francis A; Liniany, Lukasz P; Knight, David; Samsel, Leigh A; Berlinguer-Palmini, Rolando; Yim, Joshua J; Felizardo, Tania C; Eckhaus, Michael A; Edgington-Mitchell, Laura; Martinez-Fabregas, Jonathan; Zhu, Jinfang; Fowler, Daniel H; van Kasteren, Sander I; Laurence, Arian; Bogyo, Matthew; Watts, Colin; Shevach, Ethan M; Amarnath, Shoba.

Immunity ; 49(2): 247-263.e7, 2018 08 21.

Artigo em Inglês | MEDLINE | ID: mdl-30054205

6.

Ibrutinib as part of risk-stratified treatment for post-transplant lymphoproliferative disorder: The phase 2 TIDaL trial.

Chaganti, Sridhar; Maycock, Shanna; McIlroy, Graham; Jackson, Aimee E; Bishop, Rebecca; Johnson, Sarah; Kanfer, Edward; Kassam, Shireen; Cwynarski, Kate; Wrench, David J; Arumainathan, Arvind; Fox, Christopher P; Johnson, Rod J; McKay, Pamela; Paneesha, Shankara; Rowntree, Clare; Balotis, Constantine; Collins, Graham P; Davies, Andrew J; Wright, Josh; Burns, Sarah; Laurence, Arian Dominic John; Wheatley, Keith; Menne, Tobias.

Blood ; 2024 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-38643491

7.

Allogeneic stem cell transplantation compared to conservative management in adults with inborn errors of immunity.

Cheminant, Morgane; Fox, Thomas A; Alligon, Mickael; Bouaziz, Olivier; Neven, Bénédicte; Moshous, Despina; Blanche, Stéphane; Guffroy, Aurélien; Fieschi, Claire; Malphettes, Marion; Schleinitz, Nicolas; Perlat, Antoinette; Viallard, Jean-François; Dhedin, Nathalie; Sarrot-Reynauld, Françoise; Durieu, Isabelle; Humbert, Sébastien; Fouyssac, Fanny; Barlogis, Vincent; Carpenter, Benjamin; Hough, Rachael; Laurence, Arian; Marçais, Ambroise; Chakraverty, Ronjon; Hermine, Olivier; Fischer, Alain; Burns, Siobhan O; Mahlaoui, Nizar; Morris, Emma C; Suarez, Felipe.

Blood ; 141(1): 60-71, 2023 01 05.

Artigo em Inglês | MEDLINE | ID: mdl-36167031

8.

Transcription factor EB coordinates environmental cues to regulate T regulatory cells' mitochondrial fitness and function.

Xia, Minghui; Zhang, Cai; Chen, Yufei; Zhao, Xiujuan; Zhang, Si; Liu, Yang; Cai, You; Wei, Zhengping; Du, Qiuyang; Yu, Wenting; Zhou, Chun; Xiao, Hongjun; Wang, Guihua; Cheng, Xiang; Mei, Heng; Laurence, Arian; Wang, Jing; Hu, Yu; Li, Huabin; Yang, Xiang-Ping.

Proc Natl Acad Sci U S A ; 119(31): e2205469119, 2022 08 02.

Artigo em Inglês | MEDLINE | ID: mdl-35895684

9.

TIF1Î³ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis.

Wu, Yanhui; Yu, Bin; Ai, Xi; Zhang, Wei; Chen, Weixun; Laurence, Arian; Zhang, Mingzhi; Chen, Qian; Shao, Yajie; Zhang, Bixiang.

Biol Chem ; 405(4): 241-256, 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38270141

10.

Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story.

Bonelli, Michael; Kerschbaumer, Andreas; Kastrati, Kastriot; Ghoreschi, Kamran; Gadina, Massimo; Heinz, Leonhard X; Smolen, Josef S; Aletaha, Daniel; O'Shea, John; Laurence, Arian.

Ann Rheum Dis ; 83(2): 139-160, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-37923366

11.

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

Hirahara, Kiyoshi; Onodera, Atsushi; Villarino, Alejandro V; Bonelli, Michael; Sciumè, Giuseppe; Laurence, Arian; Sun, Hong-Wei; Brooks, Stephen R; Vahedi, Golnaz; Shih, Han-Yu; Gutierrez-Cruz, Gustavo; Iwata, Shigeru; Suzuki, Ryo; Mikami, Yohei; Okamoto, Yoshitaka; Nakayama, Toshinori; Holland, Steven M; Hunter, Christopher A; Kanno, Yuka; O'Shea, John J.

Immunity ; 42(5): 877-89, 2015 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-25992861

12.

The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.

Chen, Yin-Huai; van Zon, Sarah; Adams, Alex; Schmidt-Arras, Dirk; Laurence, Arian D J; Uhlig, Holm H.

J Clin Immunol ; 44(1): 30, 2023 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-38133879

13.

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.

Yang, Xiang-Ping; Ghoreschi, Kamran; Steward-Tharp, Scott M; Rodriguez-Canales, Jaime; Zhu, Jinfang; Grainger, John R; Hirahara, Kiyoshi; Sun, Hong-Wei; Wei, Lai; Vahedi, Golnaz; Kanno, Yuka; O'Shea, John J; Laurence, Arian.

Nat Immunol ; 12(3): 247-54, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-21278738

14.

CAR-T cells, the first pharmaceutical cell therapy.

Laurence, Arian.

Transfus Apher Sci ; 62(5): 103754, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37423868

15.

Retrospective, Landmark Analysis of Long-term Adult Morbidity Following Allogeneic HSCT for Inborn Errors of Immunity in Infancy and Childhood.

Day, James W; Elfeky, Reem; Nicholson, Bethany; Goodman, Rupert; Pearce, Rachel; Fox, Thomas A; Worth, Austen; Booth, Claire; Veys, Paul; Carpenter, Ben; Hough, Rachael; Gaspar, H Bobby; Titman, Penny; Ridout, Deborah; Workman, Sarita; Hernandes, Fernando; Sandford, Kit; Laurence, Arian; Campbell, Mari; Burns, Siobhan O; Morris, Emma C.

J Clin Immunol ; 42(6): 1230-1243, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35579633

16.

IL-1 watches the watchmen.

Villarino, Alejandro V; Laurence, Arian.

Nat Immunol ; 16(3): 226-7, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25689436

17.

Death-associated protein kinase 1 (DAPK1) controls CD8⁺ T cell activation, trafficking, and antitumor activity.

Wei, Zhengping; Du, Qiuyang; Li, Pingfei; Liu, Huicheng; Xia, Minghui; Chen, Yufei; Bi, Guoyu; Tang, Zhao-Hui; Cheng, Xiang; Lu, Youming; He, Ran; Laurence, Arian; Wang, Jing; Huang, Liu; Li, Huabin; Yang, Xiang-Ping.

FASEB J ; 35(1): e21138, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33184932

18.

A degrading view of regulatory T cells.

Laurence, Arian; Belkaid, Yasmine; O'Shea, John J.

Immunity ; 39(2): 201-3, 2013 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-23973216

19.

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.

Chen, Yin-Huai; Zastrow, Diane B; Metcalfe, Riley D; Gartner, Lisa; Krause, Freia; Morton, Craig J; Marwaha, Shruti; Fresard, Laure; Huang, Yong; Zhao, Chunli; McCormack, Colleen; Bick, David; Worthey, Elizabeth A; Eng, Christine M; Gold, Jessica; Montgomery, Stephen B; Fisher, Paul G; Ashley, Euan A; Wheeler, Matthew T; Parker, Michael W; Shanmugasundaram, Veerabahu; Putoczki, Tracy L; Schmidt-Arras, Dirk; Laurence, Arian; Bernstein, Jonathan A; Griffin, Michael D W; Uhlig, Holm H.

J Allergy Clin Immunol ; 148(2): 585-598, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33771552

20.

Selectivity and therapeutic inhibition of kinases: to be or not to be?

Ghoreschi, Kamran; Laurence, Arian; O'Shea, John J.

Nat Immunol ; 10(4): 356-60, 2009 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-19295632

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